Peptide Folding, Misfolding, and Nonfolding (Wiley Series in Protein and Peptide Science)

Peptide Folding, Misfolding, and Nonfolding (Wiley Series in Protein and Peptide Science)
by Reinhard Schweitzer-Stenner, Vladimir Uversky
Publication Date: March 27, 2012

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Review & Description

Sheds new light on intrinsically disordered proteins and peptides, including their role in neurodegenerative diseases

With the discovery of intrinsically disordered proteins and peptides (IDPs), researchers realized that proteins do not necessarily adopt a well defined secondary and tertiary structure in order to perform biological functions. In fact, IDPs play biologically relevant roles, acting as inhibitors, scavengers, and even facilitating DNA/RNA-protein interactions. Due to their propensity for self-aggregation and fibril formation, some IDPs are involved in neurodegenerative diseases such as Parkinson's and Alzheimer's.

With contributions from leading researchers, this text reviews the most recent studies, encapsulating our understanding of IDPs. The authors explain how the growing body of IDP research is building our knowledge of the folding process, the binding of ligands to receptor molecules, and peptide self-aggregation. Readers will discover a variety of experimental, theoretical, and computational approaches used to better understand the properties and function of IDPs. Moreover, they'll discover the role of IDPs in human disease and as drug targets.

Protein and Peptide Folding, Misfolding, and Non-Folding begins with an introduction that explains why research on IDPs has significantly expanded in the past few years. Next, the book is divided into three sections:

• Conformational Analysis of Unfolded States

• Disordered Peptides and Molecular Recognition

• Aggregation of Disordered Peptides

Throughout the book, detailed figures help readers understand the structure, properties, and function of IDPs. References at the end of each chapter serve as a gateway to the growing body of literature in the field.

With the publication of Protein and Peptide Folding, Misfolding, and Non-Folding, researchers now have a single place to discover IDPs, their diverse biological functions, and the many disciplines that have contributed to our evolving understanding of them.

Product Details

• Amazon Sales Rank: #270952 in Books
• Published on: 2012-03-27
• Original language: English
• Number of items: 1
• Dimensions: .0" h x .0" w x .0" l, .0 pounds
• Binding: Hardcover
• 592 pages

Race Decoded: The Genomic Fight for Social Justice

Race Decoded: The Genomic Fight for Social Justice
by Catherine Bliss
Publication Date: May 23, 2012

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Review & Description

In 2000, with the success of the Human Genome Project, scientists declared the death of race in biology and medicine. But within five years, many of these same scientists had reversed course and embarked upon a new hunt for the biological meaning of race. Drawing on personal interviews and life stories, Race Decoded takes us into the world of elite genome scientists—including Francis Collins, director of the NIH; Craig Venter, the first person to create a synthetic genome; and Spencer Wells, National Geographic Society explorer-in-residence, among others—to show how and why they are formulating new ways of thinking about race.

In this original exploration, Catherine Bliss reveals a paradigm shift, both at the level of science and society, from colorblindness to racial consciousness. Scientists have been fighting older understandings of race in biology while simultaneously promoting a new grand-scale program of minority inclusion. In selecting research topics or considering research design, scientists routinely draw upon personal experience of race to push the public to think about race as a biosocial entity, and even those of the most privileged racial and social backgrounds incorporate identity politics in the scientific process. Though individual scientists may view their positions differently—whether as a black civil rights activist or a white bench scientist—all stakeholders in the scientific debates are drawing on memories of racial discrimination to fashion a science-based activism to fight for social justice.

Product Details

• Amazon Sales Rank: #309219 in Books
• Published on: 2012-05-23
• Original language: English
• Number of items: 1
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• Binding: Paperback
• 280 pages

Handbook of Lipid Bilayers, Second Edition

Handbook of Lipid Bilayers, Second Edition
by Derek Marsh
Publication Date: July 2, 2012

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Review & Description

Now in its second edition, the Handbook of Lipid Bilayers is a groundbreaking work that remains the field’s definitive text and only comprehensive source for primary physicochemical data relating to phospholipid bilayers. Along with basic thermodynamic data, coverage includes both dynamic and structural properties of phospholipid bilayers. It is an indispensable reference for users of bilayer model membranes and liposome delivery systems and for those interested in the biophysics of membrane structure.

Each chapter in the second edition contains considerable amounts of explanation and elaboration, including, in many cases, extensive analysis of structural connections between the data.

New in the Second Edition:

• Chapters on crystal structures of phospholipids include new structures and more comprehensive data on bond lengths, bond angles, and torsion angles—and all coordinates are Cartesian
• Wide-angle data is indexed whenever possible to characterize chain-packing modes in gel and crystalline lamellar phases
• Low-angle data are analyzed in terms of the lipid and water thicknesses
• Headgroup separations in electron density profiles for phospholipids are included, and a separate section is devoted to the in-depth analysis of electron density profiles that provides the most detailed structural information on fluid lamellar phases
• Phase diagrams of phospholipid mixtures are vastly expanded and have been redrawn in standardized format to aid intercomparison. Cholesterol, including ternary systems, is now featured.
• New sections on titration calorimetry, and much extended data on the temperature dependence of transfer rates
• The greatly expanded chapter on bilayer–bilayer interactions features new and detailed information on the components of interbilayer pressures

Product Details

• Amazon Sales Rank: #182535 in Books
• Published on: 2012-05-22
• Original language: English
• Number of items: 1
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• Binding: Hardcover
• 1130 pages

Illustrated Guide to Home Forensic Science Experiments: All Lab, No Lecture

Illustrated Guide to Home Forensic Science Experiments: All Lab, No Lecture
by Robert Bruce Thompson, Barbara Fritchman Thompson
Publication Date: August 22, 2012

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Product Details

• Amazon Sales Rank: #602471 in Books
• Published on: 2012-08-22
• Binding: Paperback
• 400 pages

Chemistry: An Introduction to General, Organic, and Biological Chemistry (11th Edition)

Chemistry: An Introduction to General, Organic, and Biological Chemistry (11th Edition)
by Karen C. Timberlake
(10)

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Review & Description

Known for its friendly writing style and real-world, health-related applications, Timberlake’s Chemistry: An Introduction to General, Organic, and Biological Chemistry was created specifically to help prepare you for a career in a health-related profession—such as nursing, dietetics, respiratory therapy, or  environmental and agricultural science. It assumes no prior knowledge of chemistry, and makes your course an engaging and positive experience by relating the structure and behavior of matter to its role in health and the environment. The Eleventh Edition introduces more problem-solving strategies, including new concept checks, more problem-solving guides, and more conceptual, challenge, and combined problems.  

Product Details

• Amazon Sales Rank: #25557 in Books
• Brand: NA
• Published on: 2011-01-06
• Ingredients: Example Ingredients
• Original language: English
• Number of items: 1
• Dimensions: 1.00" h x 8.70" w x 10.90" l, 3.50 pounds
• Binding: Hardcover
• 744 pages

The Molecules of Life: Physical and Chemical Principles

The Molecules of Life: Physical and Chemical Principles
by John Kuriyan, Boyana Konforti, David Wemmer
Publication Date: July 31, 2012

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Review & Description

The field of biochemistry is entering an exciting era in which genomic information is being integrated into molecular-level descriptions of the physical processes that make life possible.

The Molecules of Life is a new textbook that provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences.a This new generation of molecular biologists and biochemists will harness the tools and insights of physics and chemistry to exploit the emergence of genomics and systems-level information in biology, and will shape the future of medicine.

The book integrates fundamental concepts in thermodynamics and kinetics with an introduction to biological mechanism at the level of molecular structure. The central theme is that the ways in which proteins, DNA, and RNA work together in a cell are connected intimately to the structures of these biological macromolecules. The structures, in turn, depend on interactions between the atoms in these molecules, and on the interplay between energy and entropy, which results in the remarkable ability of biological systems to self-assemble and control their own replication.

The Molecules of Life deepens our understanding of how life functions by illuminating the physical principles underpinning many complex biological phenomena, including how nerves transmit signals, the actions of chaperones in protein folding, and how polymerases and ribosomes achieve high fidelity.

Product Details

• Amazon Sales Rank: #587599 in Books
• Published on: 2012-07-31
• Original language: English
• Binding: Paperback
• 1032 pages

Harper's Illustrated Biochemistry, 28th Edition (LANGE Basic Science)

Harper's Illustrated Biochemistry, 28th Edition (LANGE Basic Science)
by Robert Murray, Victor Rodwell, David Bender, Kathleen M. Botham, P. Anthony Weil, Peter J. Kennelly
(7)

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Review & Description

The biochemistry text that every medical student must own--now in full color!

A Doody's Core Title ESSENTIAL PURCHASE for 2011!

Comprehensive, concise, and up-to-date, Harper's is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of health and disease.

The Twenty-Eighth Edition has undergone sweeping changes -- including a conversion to full-color artwork and the substantial revision and updating of every chapter -- all to reflect the latest advances in knowledge and technology and to make the text as up-to-date and clinically relevant as possible. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's Illustrated Biochemistry offers an organization and clarity not found in any other text on the subject.

Striking just the right balance between detail and brevity, Harpers Illustrated Biochemistry is essential for USMLE review and is the single best reference for learning the clinical relevance of a biochemistry topic.

NEW to this edition:

• Full-color presentation, including 600+ illustrations
• Every chapter opens with a Summary of the Biomedical Importance and concludes with a Summary reviewing the topics covered
• Two all-new chapters: "Free Radicals and Antioxidant Nutrients" and "Biochemical Case Histories" which offers an extensive presentation of 16 clinical conditions
• A new appendix containing basic clinical laboratory results and an updated one with a list of important websites and online journals
• NEW or updated coverage of important topics including the Human Genome Project and computer-aided drug delivery

Product Details

• Amazon Sales Rank: #209218 in Books
• Published on: 2009-06-02
• Original language: English
• Number of items: 1
• Dimensions: .85" h x 8.47" w x 11.00" l, 3.05 pounds
• Binding: Paperback
• 704 pages